Digital communication channels and their impact on the MA interaction with the physicians and patients. Niraparib is a selective PARP1/2 inhibitor approved as monotherapy for the maintenance treatment of adult patients with recurrent ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy. For full prescribing information, including indications, contraindications, warnings, precautions, and adverse events, please refer to the approved product labeling. P481]. 1301; Abstract A1312]. GSK is committed to monitoring the safety of our products and we encourage you or your health care provider to report any side effect or suspected overdose to GSK at 888-825-5249. Vogelmeier CF, Boucot IH, Kerwin EM, et al. POSTER: Real-World Belantamab Mafodotin (Belamaf) Use: A US Retrospective Longitudinal Pharmacy and Medical Open-Source Claims Database Assessment (Encore), 3. Real-World Impact of Triple Therapy with Fluticasone Furoate, Umeclidinium, and Vilanterol on Asthma Control among Patients with Asthma in the US. Prospective Multicenter Observational Cohort Study to Assess the Burden of HZ Disease in the Eye: Baseline Results, 5. Economic Burden of Herpes Zoster Among Individuals With COPD: A Retrospective Cohort Study, 7. Vogelmeier CF, Kerwin EM, Naya IP, et al. NY-ESO-1 and LAGE-1a are expressed in a wide range of tumor types, with restricted expression in normal tissues. 5. 4. Poster No. Efficacy of Umeclidinium/Vilanterol Versus Umeclidinium or Salmeterol: A Number-Needed-to-Treat Analysis of the EMAX Trial. and LAGE-1a?specific affinity-enhanced TCRs. Dostarlimab is a humanized anti?PD-1 mAb that binds with high affinity to PD-1 and effectively blocks interactions with PD-L1 and PD-L2. 3. Sequential Administration of Belimumab and Rituximab in Primary Sjgren?s Syndrome Reduces Minor Salivary Gland-Resident B Cells and Delays B-cell Repopulation in Circulation, 6. Front Immunol. Trends in COVID-19 Incidence Among Patients with Asthma in 2020: A Population-Based Study in the United States. Plainsboro, NJ 08536 POSTER: A Retrospective Database Analysis of Treatment Pathways in US Medicare Patients with Multiple Myeloma and Prior Exposure to Daratumumab, an Immunomodulatory Agent, and a Proteasome Inhibitor, 5. 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Describing asthma control and adherence in patients with extended Salford Lung Study (Ex-SLS) prescribed inhaled corticosteroids/long-acting beta agonists (ICS/LABAs). 2. POSTER: The Comparative Clinical Effectiveness of Dostarlimab Versus Doxorubicin in the Treatment of Advanced/Recurrent Endometrial Cancer, 4. Assessing Efficacy via Indirect Comparison of Single-Agent Belantamab Mafodotin (Belamaf; GSK2857916) in DREAMM-2 Versus STORM or MAMMOTH Studies in Relapsed/Refractory Multiple Myeloma (RRMM), 1. Outcomes Following Continuation or Stopping Long-Term Mepolizumab Treatment in Patients With Severe Eosinophilic Asthma: The Randomized COMET Trial. 13. [Poster No. This site is intended to provide balanced, scientific, and evidence-based answers to unsolicited medical questions. Conversely, the presence of this link does not imply the linked site's endorsement of Poster No. 1466. The Clinical Benefit of Mepolizumab Treatment Is Independent of Baseline Maintenance Oral Corticosteroid Use: Results From the Real-World REALITI-A Study. POSTER: Safety and Clinical Activity of Belantamab Mafodotin With Pembrolizumab in Patients With Relapsed/Refractory Multiple Myeloma (RRMM): DREAMM-4 Study, 4. Obrador GT, et al. Therapeutic Switch From Omalizumab to Mepolizumab in Patients With Uncontrolled Severe Eosinophilic Asthma: Treatment Effect by Exacerbations. Phone +1 609 430 2481, Midtown Tower United Therapeutics does not provide medical advice. [Abstract/Presentation No. P1448. 10. POSTER: ICOS co-stimulation in combination immune checkpoint blockade and/or dose-optimized focal irradiation results in enhanced tumor control, 3. Poster No. Long-term follow-up of bintrafusp alfa, a bifunctional fusion protein targeting TGF-? Pivotal DREAMM-2 Study: Single-Agent Belantamab Mafodotin (Belamaf; GSK2857916) in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) Refractory to Proteasome Inhibitors, Immunomodulatory Agents, and Refractory and/or Intolerant to Anti-CD38 Monoclonal Antibodies (mAbs), Including Subgroups with Renal Impairment (RI) and High-Risk (HR) Cytogenetics, 3. McCreary G, Yawn BP, Linnell J, et al. [Poster No. Paratek Medical Affairs Site. ORAL PRESENTATION: Dostarlimab in advanced/recurrent (AR) mismatch repair deficient/microsatellite instability?high or proficient/stable (dMMR/MSI-H or MMRp/MSS) endometrial cancer (EC): the GARNET study, 1. Nat Med. You may also report suspected adverse events to the Food and Drug Administration (FDA) directly at 1-800-FDA-1088 or www.fda.gov/MedWatch. If not, try adjusting your search terms or contact GSK Medical Information at 1-877-GSK-MI4U (1-877-475-6448). 1. 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[Poster No. POSTER: The Time Course of Adverse Events During Dostarlimab Treatment in Mismatch Mutation Repair Deficient and Proficient Endometrial Cancer Patients in the GARNET Trial, 2. Clinical Burden of Chronic Rhinosinusitis with Nasal Polyps in Patients with Severe Eosinophilic Asthma: A Post Hoc Analysis of Data from MENSA and COSMOS. discussions with a healthcare provider. Genmab Medical Information is your resource for timely information relating to Genmab products. PLAIN LANGUAGE SUMMARY [HCP USE ONLY]: ENGOT-EN6/GOG-3031/ NSGO-RUBY: A Phase 3, Randomized, Double-Blind, Multicenter Study of Dostarlimab + Carboplatin? Comparative Efficacy of Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Versus Other Triple Therapies for the Treatment of Chronic Obstructive Pulmonary Disease (COPD): A Systematic Literature Review and Network Meta-Analysis. P1445. Characterization of severe asthma patients affiliated to the Hospital Italiano Medical Care Program in Buenos Aires, Argentina. POSTER: The impact of increased RZV use on the burden of herpes zoster among adults aged 50 to 59 Years. POSTER: Who receives maintenance therapy after first-line chemotherapy? 3. The Genmab Medical Affairs website provides healthcare professionals with easily accessible information about our products and ongoing clinical research. See product details, storage & handling info for GSK vaccines, and more. A Phase 1 study of TSR-022, an Anti-TIM-3 monoclonal antibody, in combination with TSR-042 (Anti-PD-1) in patients with colorectal cancer and Post-PD-1 NSCLC and melanoma, 2. Teams, however, can vary in their mission, scope of services, and organizational structure, and further responsibilities can include: Medical Affairs Team Members Can Include: If you enjoyed reading this article, you might also like to read Reach New Heights in a New Medical Careers Role.. [Oral presentation available here; Abstract A6247]. The site you are linking to is not controlled or endorsed by GSK and GSK is not responsible for its content. POSTER: Efficacy and safety of dostarlimab in patients (pts) with mismatch repair deficient (dMMR) solid tumors: analysis of 2 cohorts in the GARNET study, 10. 2017;31(2):101-1261. PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes. Preclinical evaluation of a non-depleting, first-in-class humanized IgG4 agonist anti-ICOS antibody, 2. The Impact of Comorbid Nasal Polyps on Real-World Mepolizumab Effectiveness in Patients with Severe Asthma: Results from the REALITI-A Study. 1. Assessment of Asthma Control in Respiratory Specialist Offices in the US. [Poster No. GSK3368715, a type 1 PRMT inhibitor, is being investigated in phase I trials for patients with diffuse large B-cell lymphoma and solid tumors. POSTER: First real-life data on niraparib maintenance in newly-diagnosed advanced ovarian cancer: a descriptive analysis of the Temporary Authorisation for Use (ATU) cohort, 2. 1. Oral presentation. Rescue Medication Use as an Indicator of Symptom Burden in Patients With COPD: A Post Hoc Analysis of the EMAX Trial. ORAL PRESENTATION: Dostarlimab in advanced/recurrent mismatch repair deficient/microsatellite instability high or proficient/stable endometrial cancer: the GARNET study, 2. Connect With Our Medical Team. 5. 1. Association between TGF-? The Adjuvanted Recombinant Zoster Vaccine Confers Long-Term Protection Against HZ: Interim Results of an Extension Study of Two Clinical Trials, 7. Medical affairs is the unique organization within a life sciences company that focuses on the communications between the company and medical professionals, healthcare providers, and patients. PUBLICATION ONLY: Treatment Patterns of Advanced or Recurrent Endometrial Cancer Following Platinum-Based Therapy in the US Real-World Setting, 23. Evaluation of the Psychometric Properties, Scoring Algorithm, and Score Interpretation of the E-RS: Asthma in Two Clinical Trials of Moderate to Severe Asthma. Together with over 9,000 Medical Affairs members from 280+ companies globally, MAPS is transforming the Medical Affairs profession to increase its value to patients, HCPs, industry and society. Impact of Systemic Corticosteroid (SCS) Exposure on SCS-Related Complications Among Patients with Asthma in the US. Mullol J, Lund V, Wagenmann M, et al. P805; Abstract A7742]. Cancer Cell.2019;36(1):100-114. POSTER: Safety and Clinical Activity of Belantamab Mafodotin With Lenalidomide Plus Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma (RRMM): DREAMM-6 Arm-A Interim Analysis, 3. Poster No. Clinical research Explore our ongoing clinical trials. National Differences in Real-World Outcomes with Mepolizumab Treatment for Patients with Severe Asthma: Results from the REALITI-A Study. POSTER: Treatment Patterns Among Patients with Relapsed/Refractory Multiple Myeloma (RRMM) Receiving Second- and Third-Line Therapy in a Medicare Population, 2. They synthesize information and translate findings about therapeutics/drugs into language that can be better understood by company staff whose primary expertise is not scientific. www.vaers.hhs.gov to file a report, or call Seo J, Zhang S, Zhang D, et al. 4. Real-World Safety and Effectiveness of Fluticasone Furoate/Vilanterol in Patients with Asthma or Chronic Obstructive Pulmonary Disease: A Post-Marketing Study in Korea. Access MAPS articles, white papers, standards & guidance, eLearning courses, webinars, podcasts and more for the following Medical Affairs functions. 1. 373. Demographic and clinical characteristics of patients experiencing on-treatment exacerbations, on-treatment death or premature study treatment withdrawal: The IMPACT Trial. and physicians? Paclitaxel Versus Placebo + Carboplatin?Paclitaxel in Recurrent or Primary Advanced Endometrial Cancer, 7. CAPTAIN Study: Simultaneous Step-up to High Dose Fluticasone Furoate and Addition of Umeclidinium for the Treatment of Inadequately Controlled Asthma. POSTER: Safety and Efficacy of Letetresgene Autoleucel (lete-cel; GSK3377794) Alone or in Combination with Pembrolizumab in Relapsed and Refractory Multiple Myeloma, 8. 4. Bogart M, Bengtson L, Rothnie K, et al. Voice of the patient integration into Medical Affairs activities - insights and involvement. Poster No. Treatment Patterns and Disease Burden of Triple Therapy in Asthma. Genmab makes no representation regarding the accuracy of the information on this site. 2. Whittaker HR, Rothnie K, Quint JK. Bogart M, Germain G, Lalibert F, et al. Cost-effectiveness evaluation of sotrovimab, a monoclonal antibody, for the treatment of mild-to-moderate COVID-19 in patients at high risk of disease progression. Bintrafusp alfa is a bifunctional fusion protein composed of the extracellular domain of the human transforming growth factor ? Goodall E, Wood R, Numbere B, et al. 2. A Population Study. Areas, Search Medical The PLUTO study: intravenous belimumab in children with systemic lupus erythematosus, 3. Cross-sectional survey to assess chronic obstructive pulmonary disease (COPD) medication use by United States (US) physicians. Associations of haemoglobin values and rate of changes with MACE in the ASCEND-D randomised clinical trial. P0018. Singh AK, et al. This site is intended for US Patients or Caregivers. BLISS-LN OLE: A 6-Month Open-Label Extension Study of the Safety and Efficacy of Intravenous Belimumab in Patients With Lupus Nephritis, 2. Analysis of a Composite Endpoint of Exacerbation and Early Study Treatment Withdrawal in Symptomatic Patients With COPD Free of Inhaled Corticosteroids: A Post Hoc Analysis of the EMAX Trial. Oncotarget. Slade D, Ray R, Moretz C, et al. 14. CAPTAIN Study: Evaluating the Efficacy of Once-Daily, Single-Inhaler Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Versus FF/VI in Inadequately Controlled Asthma Using Change in Asthma Control Questionnaire and the Relationship With Trough FEV1. CAPTAIN: Effects of age as a continuous variable on asthma control. Hemoglobin Efficacy and Cardiovascular Safety Data from the ASCEND-ND, -D, and -ID Trials. This site is intended for US healthcare professionals only. J Clin Invest. JASPER: Efficacy and Safety of First-Line (1L) Niraparib Plus a Programmed Death Receptor-1 Inhibitor (PD-1i) in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC), 6. Helping the brand team in formulating scientific strategy. 2. POSTER: Phase 2 platform trial of anti-T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) GSK?859A/EOS-448 plus anti-programmed death-1 (PD-1) dostarlimab in patients with non-small cell lung cancer (NSCLC), June 9-12, 2022 | Vienna, Austria | Virtual, 2. Bogart M, Han X, Bengtson L, et al. The Impact of Comorbidities and Clinical Characteristics on Real-World Mepolizumab Effectiveness in Patients With Severe Asthma: Results From the REALITI-A Study. Clinical Burden of Chronic Rhinosinusitis with Nasal Polyps in Patients with Severe Eosinophilic Asthma: A Post Hoc Analysis of Data from MENSA and COSMOS. [Abstract/Poster No. ORAL PRESENTATION: OVARIO, A Phase 2 Study of Niraparib + Bevacizumab in Advanced Ovarian Cancer Following Front-Line Platinum-Based Chemotherapy with Bevacizumab: Updated Analysis, 2. MOONSTONE: A Phase 2 Open-Label, Single-Arm Study to Evaluate the Efficacy and Safety of the Combination of Niraparib and Dostarlimab in Patients With Platinum Resistant Ovarian Cancer (TiP), 5. 2. providing these links to you only as a convenience and the inclusion of any link does not imply the Impact of the COVID-19 Pandemic on Dispensing of Respiratory Therapies Among Patients with Chronic Obstructive Pulmonary Disease (COPD) in the United States: A Population-Based Study. Kerstjens HA, Pavord ID, Peachey G, et al. 811; Abstract A4300]. You will now be taken from the GSK U.S. Medical and Physicians? Seo J, Zhang S, Krucien N, et al. Impact of the COVID-19 Pandemic on Chronic Obstructive Pulmonary Disease (COPD) Exacerbations in the United States: A Population-Based Study. POSTER: Early COVID-19 Treatment With SARS-CoV-2 Neutralizing Antibody Sotrovimab. Impact of the COVID-19 Pandemic on Asthma Exacerbations in the United States: A Population-Based Study. Comparative Efficacy of Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Versus Other Triple Therapies for the Treatment of Chronic Obstructive Pulmonary Disease (COPD): A Systematic Literature Review and Network Meta-Analysis. 2. 1. CAPTAIN Study: Simultaneous Step-up to High Dose Fluticasone Furoate and Addition of Umeclidinium for the Treatment of Inadequately Controlled Asthma. 2015;5:34, Aspeslagh S, Postel-Vinay S, Rusakiewicz S, Soria JC, Zitvogel L, Marabelle A. [Poster No. NY-ESO-1 and LAGE-1a are widely expressed in diverse tumor types with restricted expression in normal tissues. Review our products currently in development. Genes Dev. 1. 2017;47(5):765-779. 6. 1. about disease states including Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis. Did this answer your question? 3. POSTER: Safety and Clinical Activity of Belantamab Mafodotin With Lenalidomide Plus Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma (RRMM): DREAMM-6 Arm-A Interim Analysis, 3. P1505. Meta-analysis From Two Phase 3 Trials. Smith SG, Price R, Mollo MR, et al. POSTER: Progression-free survival (PFS) and overall survival (OS) in patients (pts) with mismatch repair deficient (dMMR) solid tumors treated with dostarlimab in the GARNET study, 7. ORAL PRESENTATION: DREAMM-5 Study: Investigating the Synergetic Effects of Belantamab Mafodotin plus Inducible T cell Co-Stimulator Agonist (aICOS) Combination Therapy in Patients with Relapsed/Refractory Multiple Myeloma, 1. Assessment of Asthma Control in Respiratory Specialist Offices in the US. Understanding heterogeneity in patient preferences for maintenance inhaler therapies in asthma. Internally, Medical Affairs bridges the research and commercial sides of the business. Tokyo 107-6235 Bjermer L, Maltais F, Vogelmeier CF, et al. PO0465, ASCEND-TD: A randomized, double-blind, active-controlled study of daprodustat administered three-times-weekly in hemodialysis patients. DREAMM-7: A Phase III Study of the Efficacy and Safety of Belantamab Mafodotin (Belamaf) with Bortezomib, and Dexamethasone (B-Vd) in Patients with Relapsed/Refractory Multiple Myeloma (RRMM), 9. 2018;7(5):e1426519. Verhamme K, de Ridder M, Webb D, et al. Singh AK, et al. You are encouraged to report vaccine adverse reactions to the US Department of Health and Human Services. 3. Bernstein D, Liu MC, Schleich F, et al. 9. The Impact of Baseline Exhaled Nitric Oxide Levels and Blood Eosinophil Count on Clinical Outcomes in REALITI-A. 1560 Copenhagen V 10. Start with your customer. Brain Metastases in Primary Ovarian Cancer: Real-world Data, 1. Blood. Safety of Belimumab in Adult Patients With Systemic Lupus Erythematosus: A Large Integrated Safety Analysis of Controlled Clinical Trial Data, 1. Comparative Efficacy of UMEC/VI Versus Other Bronchodilators for the Treatment of COPD: A Systematic Literature Review and Network Meta-Analysis. P1446. 2. All decisions regarding patient care must be made by a POSTER: RSVPreF3 OA Candidate Vaccine Safety Presentation. Massachusetts Registry of Motor Vehicles Disability Plates and Placards Through Medical Affairs, the RMV issues special license plates and placards to people with disabilities who meet certain medical qualifications. [Abstract/Poster No. Medical Affairs Genmab is an international biotechnology company with a core purpose of improving the lives of people with cancer. A Population Study. Anti-tumor activity of the type I PRMT inhibitor, GSK3368715, synergizes with PRMT5 inhibition through MTAP loss. SYMPOSIUM: Managing immune-related adverse events with checkpoint inhibitors, 1. The information provided on this website is for informational purposes and is not intended to promote the use of any product. Rothnie K, Han X, Bengtson L, et al. 4. www.fda.gov/medwatch. Cho E-Y, Lee E-B, Yang S-H, et al. The phosphoinositide 3-kinase (PI3K)/protein kinase (AKT) signaling pathway plays a major role in regulating cellular process involved in cancer, including proliferation, growth, survival, and migration. Analysis of a Composite Endpoint of Exacerbation and Early Study Treatment Withdrawal in Symptomatic Patients With COPD Free of Inhaled Corticosteroids: A Post Hoc Analysis of the EMAX Trial. Initiating Mepolizumab. 1. Benefits of Initiating Single-Inhaler Triple Therapy (SITT) with Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Versus Multiple-Inhaler Triple Therapy (MITT) Among Medicare Advantage with Part D Beneficiaries with Chronic Obstructive Pulmonary Disease (COPD). USA POSTER: Immune-related endpoints in patients with advanced or recurrent endometrial cancer treated with dostarlimab in the GARNET study (IGCS ENCORE), 12. Symptom Burden in Medicare Advantage Patients with COPD Initiating Umeclidinium/Vilanterol or Fluticasone Propionate/Salmeterol Therapy. Zejula [summary of product characteristics]. Immunol Rev. Open-label, single-arm study evaluating the antitumor activity and safety of niraparib as neoadjuvant treatment in patients with localized, HER2-negative, BRCA-mutant breast cancer, 1. Bogart M, Wu B, Germain G, et al. 518; Abstract A4579]. Safety and reactogenicity of RZV: Experience from clinical trials and post-marketing.Poster F\AAFP 2021, 1. Smith E, Zhou W, Shindiapina P, Sif S, Li C, Baiocchi RA. Views of US pulmonologists on the prevalence of uncontrolled asthma, treatment decisions and the role of treatable traits: results from the CHEST Pulse Surveys. The Potential for Reducing Opioid and Analgesic Prescriptions via Herpes Zoster Vaccination, 8. 2019 GSK group of companies or its licensor. Liu MC, Schleich F, Lee JK, et al. 2. CAPTAIN Study: Daily Digital Spirometry and Symptom Data for Once-Daily, Single-Inhaler Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) in Asthma. 4. Lu E, Mu G, Alfonso-Cristancho R. T-cell immunoglobulin and mucin domain-3 (TIM-3), is a negative regulatory checkpoint molecule that regulates T-cell exhaustion, dampens the antitumor immune response, and may promote tumor cell migration and invasion. Mepolizumab Treatment Leads to Clinical Asthma Remission in Patients with Severe Eosinophilic Asthma: Results from the Real-World REDES Study. Seifert L, Werba G, Tiwari S, et al. Asthma control among the treated U.S. asthma population in Practice Fusion?s Electronic Medical Record Research Database, 2015-2018. PRMT5 is overexpressed in multiple tumor types, including lymphoma and breast, lung, and bladder cancer, and regulates splicing, gene expression, and activation of p53. ORAL PRESENTATION: Non-OS endpoints in oncology: strategies to bridge the gap in value attribution by regulators, payors, oncologists, and patients, 1. Mepolizumab Demonstrates Real-World Clinical Effectiveness in Both Type 2 Biomarker High and Type 2 Biomarker Low Patients With Severe Asthma. ORAL PRESENTATION: Efficacy of Niraparib by Timing of Surgery and Residual Disease: A Post-Hoc Analysis of Patients in the PRIMA/ENGOT-OV26/GOG-3012 Study, 1. POSTER: Real-World Trends of PARPi Maintenance Treatment Uptake and Progression-Free Survival (PFS) in Patients (pts) with Newly Diagnosed Advanced Ovarian Cancer (AOC) in the US, 8. Niraparib + Pembrolizumab (Pembro) Versus Placebo + Pembro 1L Maintenance Therapy in Advanced NSCLC: ZEAL-1L Phase III Study, 2. Impact of the COVID-19 Pandemic on Dispensing of Respiratory Therapies Among Patients with Asthma in the United States: A Population-Based Study. GSK3359609 is being actively evaluated in a number of clinical trials in solid tumors, including head and neck squamous cell carcinoma and NSCLC either as monotherapy or in combination with currently available immunomodulatory agents and anticancer therapies. With tiotropium monotherapy in Chronic Obstructive medical affairs website Disease: a Population-Based Study in the ASCEND-ND -D! The Evolving therapeutic Landscape in Patients with Severe Asthma discontinue biologic Treatment Data 24! You need assistance or have feedback about this service call US at 860-437-5700 or email customer. 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