2021 Jan;81:103497. doi: 10.1016/j.etap.2020.103497. Dipropylene Glycol Dibenzoate is a polar, high-solvating plasticizer. Keywords: WHO said laboratory analysis of samples of each of the four products confirmed that they contain unacceptable amounts of diethylene glycol and ethylene glycol as contaminants. Epub 2017 Jul 7. At the request of the United States, the State Food and Drug Administration of China investigated Taixing Glycerine Factory and CNSC Fortune Way, but the agency concluded it is not under their jurisdiction because the factory is not certified to make medicine. [57][58] Days later, Colgate-Palmolive found counterfeit toothpaste with its name, which was contaminated with DEG and found at dollar-type discount stores in New York, New Jersey, Pennsylvania and Maryland. Description. Benzo Flex 2-45; Benzoic acid, diester with diethylene glycol; Dibenzoyldiethyleneglycol ester; 2,2'-Oxydiethylene dibenzoate; 2-[2-(Benzoyloxy)ethoxy]ethyl benzoate; Ethanol, 2,2'-oxybis-, 1,1'-dibenzoate; oxydiethylene dibenzoate Permanent link for this . 8600 Rockville Pike Molecular Formula. [48], The New York Times reported that Taixing was closed by the Chinese government and CNSC Fortune Way, which is also owned by the Chinese government, was never sanctioned. Patients were treated with fluid hydration and correction of acidosis, but some were not able to survive. The industry generally operates to maximize MEG production. Its synonyms include 2-(2-butoxyethoxy)-ethanol, butoxydiglycol, butadigol, and butyl carbitol. Related topics 2 relations . Differential Hepatic Gene Expression Profile of Male Fathead Minnows Exposed to Daily Varying Dose of Environmental Contaminants Individually and in Mixture. Industry Circular No. Diethylene Glycol (DEG) is a sweet-tasting colorless, odorless, clear chemical compound product in the form of liquid that is used widely in the chemical and petrochemical industry around the world. [15] In the case of DEG, observations demonstrated there were no calcium oxalate crystal deposits in the kidneys, implying ethylene glycol is not on the DEG metabolic pathway. EINECSNO:204-407-6. It K-FLEX 500 by LANXESS (previously Emerald Kalama Chemical) is a non-phthalate, general-purpose, polar plasticizer. MeSH Product Type Native/Parent. metal, wooden and plastic construction and building [50], Panama's case made CDC set standardized methodology for DEG identification, hoping to have more timely response in future events. [47] The following month, the Toxicology Department of the Institute of Legal Medicine and Forensic Science published a list of 1,155 names whose medicine bottles tested positive for DEG. The fiscal attorney urged affected citizens to approach the Public Ministry to update the official legal file and for further medical analysis. spectrum (can be printed in landscape orientation). It displays excellent wet tack, set times and open time performance. Later, raw glycerin was analyzed and results revealed 22.2% v/v DEG. Technology, Office of Data Doctors prescribed glycerine for its osmotic diuretic effect, but patients started to develop kidney failure. H. 18. [46], In August 2009, the Supreme Court decided to send the diethylene glycol file to the Public Ministry for an extension. DEG is used as a building block in organic synthesis, e.g. Obesity II: Establishing causal links between chemical exposures and obesity. It achieves K-FLEX 975P by LANXESS (previously Emerald Kalama Chemical) is a non-phthalate, low vapor pressure-VOC plasticizer. It is a cost-effective, monomeric benzoate that is clear liquid in appearance. Epub 2009 Aug 7. Clipboard, Search History, and several other advanced features are temporarily unavailable. Exhibits UV-, oil-, solvent- and stain- resistance A Sustainable Approach to Sealant and Adhesive Formulation, Polymers>Polychlorovinyls (PVC, PVDC)>Polyvinyl Chlorides (PVC), Polymers>Polyurethanes>Thermoplastics (TPUs), Polymers>Ethylene Co-terpolymers - Solids (EVA, EMA), Polymers>Polyvinyl Acetate Emulsions & Derivatives (PVAc), Adhesives>Water-based>Pressure sensitive (PSA), Polymers>Ethylene Co-terpolymers - Emulsions (VAE, EVC), Polymers>Polyolefins>Polyethylene & Derivatives, Polymers>Polyurethanes>Polyurethane Dispersions (PUDs), Now On-Demand: Sustainable approach to sealant & adhesive formulation. It is a blend of dipropylene glycol- and diethylene glycol dibenzoate. Chemosphere. Soon thereafter, patients died after receiving the medication. From the chemical reaction between the oxidation of Ethylene with water at very high temperatures with the presence of Silver Oxide as the catalyst, Mono Ethylene Glycol (MEG) and Diethylene Glycol (DEG) are produced. [39] By June 1996, with no idea what was causing the epidemic, the Pan American Health Organization (PAHO) Haiti representative contacted the World Health Organization (WHO, the parent agency of PAHO), and WHO requested that the Centers for Disease Control and Prevention investigate.[40][33][41]. Residues listed in 40 CFR 180.910 [formerly 40 CFRS 180.100(c)] are exempted from the requirement of a Naomi R, Yazid MD, Bahari H, Keong YY, Rajandram R, Embong H, Teoh SH, Halim S, Othman F. Int J Mol Sci. +49 34291 3372-39 contact@hpc-standards.com: Emergency telephone number errors or omissions in the Database. : 680615: Relevant identified uses of the substance or mixture: Identified: Laboratory chemical uses: R&D: Uses advised against: HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. Diethylene Glycol Dibenzoate (122-62-3) is Liquid. Diethylene Glycol (MEG) is a toxic and hazardous liquid and workers must be trained and wear appropriate personal protective equipment when working with the Diethylene Glycol (MEG) product. Other important uses and applications of Diethylene Glycol (DEG) are antifreeze, brake . : D49-1; NC0019001; NC1483257; XXD494LI Synonyms 2,2`-Oxydiethanol; Diethylene glycol; Diglycol Recommended Use Laboratory chemicals. The resulting product is two ethylene glycol molecules joined by an ether bond. It is a blend of dipropylene glycol dibenzoate and diethylene glycol dibenzoate. Massengill Co. (a Tennessee drug company), manufactured sulfanilamide dissolved with diethylene glycol, to create a liquid alternative of this drug. Kassotis CD, Vom Saal FS, Babin PJ, Lagadic-Gossmann D, Le Mentec H, Blumberg B, Mohajer N, Legrand A, Munic Kos V, Martin-Chouly C, Podechard N, Langout S, Touma C, Barouki R, Kim MJ, Audouze K, Choudhury M, Shree N, Bansal A, Howard S, Heindel JJ. Vos records revealed the syrup had been bought from Sinochem International Chemicals Company through a German trader, Metall-Chemie. Epub 2020 Feb 28. Panama awaits the extradition of Criado for her hearing. 3 (Figure 1) with a molecular weight of 162.23, boiling temperature of 230.4 C, and melting point of -68.1C. [3] It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. After ingestion, DEG is absorbed through the gastrointestinal tract and distributed by the bloodstream throughout the body, reaching peak blood concentrations within 30 to 120 minutes. its accompanying search program. It is slightly soluble in water and very soluble in polymers. It is a clear, colorless liquid. View information & documentation regarding Diethylene glycol dibenzoate, including CAS, structure & more. [15] The major cause of ethylene glycol toxicity is the accumulation of glycolic acid in the body,[16] but the accumulation of calcium oxalate crystals in the kidneys can also lead to acute kidney failure. [6] It is also a component in brake fluid, lubricants, wallpaper strippers, artificial fog and haze solutions, and heating/cooking fuel. 45 Austrian, 5 German and 12 Italian wines tested positive for DEG. Most ethylene glycol antifreeze contains a few percent diethylene glycol, present as a byproduct of ethylene glycol production. Fundam Clin Pharmacol. Some authors suggest the minimum toxic dose is estimated at 0.14mg/kg of body weight and the lethal dose is between 1.0 and 1.63 g/kg of body weight,[7] while some suggest the LD50 in adults is of ~1 mL/kg,[2] and others suggest this is the LD30. Study on Spectrophotometric Determination of Iron by Using Polyethylene Glycol-ammonium sulfate-1,10-phenanthroline as Extracting System. This triggered the installation of more sensitive laboratory equipment in Banafi laboratories, Italy, and stronger alcohol regulations in Austria. This same property also makes it useful in the treatment of paper, cork, glue, and cellophane and it is utilised as a dehydrant in . One of the main uses of Diethylene Glycol (DEG) is as the intermediate product for in manufacturing of unsaturated polyester resins, plasticizers, acrylate, methacrylate resins, and urethane. Behavioural effect of low-dose BPA on male zebrafish: Tuning of male mating competition and female mating preference during courtship process. eCollection 2021. It is also used as a solvent for coatings, inks, and other applications. The Dutch authorities assessed a $250,000 fine against Vos B.V., for not alerting anyone when they tested the syrup and found impurities.[42]. Any use in a consumer product. This Sunscreen Milk SPF 30 PA +++ is a water-in-silicone sunscreen milk that delivers high and broad UV protection with soft, light and smooth skin feel. Is bisphenol A an environmental obesogen? Its main component is DIETHYLENE GLYCOL DIBENZOATE. Standard Reference Data Act. The LD50 for small mammals has been tested at between 2 and 25g/kg, less toxic than its relative ethylene glycol, but still capable of causing toxicity in humans (in high concentration only). In the tobacco industry, Diethylene Glycol (DEG) is used as a humectant in tobacco products for controlling the moisture of the tobacco filler. Di(ethylene glycol) dibenzoate (DEGDB) is a widely used dibenzoate ester based plasticizer, which has either linkages at the center that connect the two benzoate groups. ( DIETHYLENE GLYCOL DIBENZOATE) CAS No. Diethylene glycol is used in the manufacture of saturated and unsaturated polyester resins, polyurethanes, and plasticizers. Further investigation revealed all patients were treated with topical silver sulfadiazine ointment that contained 7g/kg of DEG. : 680615: Relevant identified uses of the substance or mixture: Identified: Laboratory chemical uses: R&D: Uses advised against: HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. and Informatics, NIST Mass Spectrometry Data Center, William E. Wallace, director, Modified by NIST for use in this application. Soon, patients from other parts of the country started to arrive at hospitals. It is compatible with a wide range of polar polymers and rubbers. The study revealed a strong association between ingestion of two locally produced acetaminophen liquid products (Afebril and Valodon) and illness. The product was recalled and after an investigation, the Drug Controller General of India, VG Somani, said at India Pharma 2020, that the GMP was not followed, and negligence was found during the production process itself. The other major uses and applications of Diethylene Glycol (DEG) are cement grinding, and petroleum solvent extraction also found in the printing ink and drywall joint compounds. [4] Hemodialysis may either be administered alone or in combination with ethanol or fomepizole. SAFETY DATA SHEET Creation Date 08-Jul-2014 Revision Date 24-Dec-2021 Revision Number 5 1. In the present study, we exposed zebrafish to three different BPA doses (5; 10; 20 g/L) and five different doses of DGB (0.01; 0.1; 1; 10; 100 g/L) for a period of 21 days, and investigated transcript levels for genes involved in lipid metabolism as well as measuring liver content of phosphates, lipids and proteins. They also arrested 12 people in connection with the incident. Although there is limited information about toxicokinetics in humans, observations in mass poisonings and experimental studies suggest the following information: The principal method of absorption is through oral ingestion. Dipropylene Glycol Dibenzoate is useful in applications such as latex caulks, adhesive, and sealants, coatings and vinyl plastisols. It. Di (propylene glycol) dibenzoate (DPGDB) is a widely used plasticizer that has ether linkages linked with two benzoate groups. Used as a solvator for PVC, plasticizer in elastomers, in vinyl flooring, adhesives, latex caulks and sealants, color concentrates for PVC, and castable polyurethanes; [EPA ChAMP . [66][67], The Nigerian government traced the diethylene glycol to an unlicensed chemical dealer in Lagos, who sold it to a local pharmaceutical manufacturer. This compound chemical toxic liquid is used in the treatment of papers, corks, glues, and cellphones, also one of the very useful applications of Diethylene Glycol (DEG) is in the removal of water from the gas in the gas industry. Enter the desired X axis range Lead CDC investigator Dr. Katherine O'Brien conducted a case-control investigation, looking for potential clues to the epidemic. Disclaimer, National Library of Medicine Country: P.R.China Phone: +86-571-86217390 Telefax: +86-571-86217391. Applications: Water Born Adhesives,coatings,paints, PVC Resilient Flooring,Automotive Primer,caulks,paints. of morpholine and 1,4-dioxane. [51], During June 2011, the number of confirmed deaths according to the official list rose to 219 victims [52], In May 2007, a Panamanian named Eduardo Arias discovered a 59-cent toothpaste that was labeled containing DEG. Di(ethylene glycol) dibenzoate (DEGDB) is a widely used dibenzoate ester based plasticizer, which has either linkages at the center that connect the two benzoate groups. Dermal absorption is very low, unless it is administered on broken or damaged skin. : 120-55-8. It is a blend of diethylene glycol-, dipropylene glycol- and propylene glycol Diethylene glycol dibenzoate. Identification Product Name Diethylene Glycol (Reagent) Cat No. Wang declared that after making the first order of counterfeit syrup, he swallowed some of it. When urine analyses for a series of metals, pesticides or their metabolites resulted negative, CDC scientists recalled the Nigeria and Haiti incidents. This site needs JavaScript to work properly. 2018. Gihi Chemicals Co., Limited is supplier for Diethylene glycol dibenzoate. This compound chemical toxic liquid is used in the treatment of papers, corks, glues, and cellphones, also one of the very useful applications of Diethylene Glycol (DEG) is in the removal of water from the gas in the gas industry. As a replacement for phthalate plasticizers recommended by the European Chemical Agency (ECHA), it has been used for many years in a wide variety of applications . Alfa Chemistry offers Diethylene glycol dibenzoate for experimental / research use. It is used as a rubber polymerization activators and retardants. As a result authorities in Indonesia banned all syrup medicines. It also improves adhesion to acrylic latex caulks and is a high . Data from NIST Standard Reference Database 69: The National Institute of Standards and Technology (NIST) (e.g., Japan AIST/NIMC Database- Spectrum MS-NW-5390. Viscous straw-colored liquid with a faint odor; [CHRIS] Colorless liquid with a mild ester odor; [EPA ChAMP: Submissions - Robust Summaries] Sources/Uses. The https:// ensures that you are connecting to the The symptoms seemed to match with GuillainBarr syndrome, but these patients were also losing their ability to urinate, a symptom not related to GuillainBarr.
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